tag:blogger.com,1999:blog-40659586298439317972024-03-05T01:33:51.513-05:00UMBTCThe mission of the Upper Michigan Brain Tumor Center is to empower patients and families through advocacy, education, treatment and research.
Our vision is to be your choice for comprehensive brain tumor care.
Our message is HOPE STARTS HERE.RARhttp://www.blogger.com/profile/04647511597212113412noreply@blogger.comBlogger35125tag:blogger.com,1999:blog-4065958629843931797.post-48384316224679316502013-04-08T13:51:00.000-04:002013-04-08T13:51:42.246-04:00The UMBTC Blog is relocatingIn order to provide a more streamlined experience, the UMBTC Blog will now be part of the UMBTC website, <a href="http://www.hopestartshere.org/">www.hopestartshere.org</a>.<br />
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We have transferred over all of our previous posts. Just click on the Blog link in the navigation bar up top and you will be brought to a page with all of our posts--past and present.<br />
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We appreciate your support over the years, and we hope you will continue to read our blog.<br />
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Thanks,<br />
UMBTCRARhttp://www.blogger.com/profile/04647511597212113412noreply@blogger.com0tag:blogger.com,1999:blog-4065958629843931797.post-88534676123818381552011-07-29T21:01:00.002-04:002011-07-29T22:19:20.955-04:00More Confusing Data Regarding Mobile Phone Use and Brain TumorsOn May 31, 2011, the World Health Organization (WHO) through the International Agency for Research on Cancer (IARC) classified mobile phone use as Group 2B or "possibly carcinogenic." A panel of 31 experts reached this conclusion after reviewing existing data--no new research was performed. Unfortunately, the classification as "possibly carcinogenic" by the WHO is essentially meaningless and provides the public with no useful information.<div><br /></div><div>The most recent scientific article to address this issue, "Mobile Phone Use and Brain Tumors in Children and Adolescents: A Multicenter Case–Control Study," was published in the Journal of the National Cancer Institute on July 27, 2011. This was a multi-center case-controlled study conducted in Denmark, Sweden, Norway and Switzerland and included all patients aged 7-19 years diagnosed with a brain tumor. 352 brain tumor patients and 646 controls were interviewed regarding cell phone usage. </div><div><br /></div><div>The conclusion that has received widespread press is that "Our primary analysis does not point to a statistically significantly increased risk for brain tumors in children that is associated with the use of mobile phones." In other words, cell phone use does not cause brain tumors in children or adolescents.</div><div><br /></div><div>But is that the conclusion that should really be reached from this study? Short answer: NO.</div><div><br /></div><div>First, the methodology is the repeatedly used and notoriously flawed case-control interview. This method has a variety of sources of error and it is unclear why it continues to be used and, importantly, funded.</div><div><br /></div><div>Second, at least some funding is provided by major telecommunication companies: TellaSonera, Erickson AB and Telenor.</div><div><br /></div><div>Third, when actual usage and subscription data are analyzed (as opposed to subjective interview data), the authors found "<b>a statistically significantly increased risk among users with the longest period since first subscription</b>." In other words, the risk of developing a brain tumor increased with longer cell phone use. <i>Oddly, this conclusion did not make the headlines.</i></div><div><br /></div><div>And lastly, the question asked in this study is close to but not quite what most of us want answered: Does the use of cell phones in childhood and adolescence increase the risk of developing a brain tumor in adulthood?</div><div><br /></div><div>So, what is the take home message? The data on cell phone use and risk of brain tumor is conflicting. At this point, the published studies have limitations ranging from methodology errors, to funding conflicts of interest.</div><div><br /></div><div>What should you do? Use the speaker phone feature. Use text messaging (except when driving). And limit mobile phone usage in children and adolescents.</div><div><br /></div>RARhttp://www.blogger.com/profile/04647511597212113412noreply@blogger.com0tag:blogger.com,1999:blog-4065958629843931797.post-66982941270668870542011-02-24T16:33:00.002-05:002011-02-24T17:09:27.129-05:00More Updates on Cell Phone Usage and and Brain TumorsThe current issue of the Journal of the American Medical Association (<span class="blsp-spelling-error" id="SPELLING_ERROR_0">JAMA</span>, February 23, 2011), details a never before studied aspect of cell phone-brain interaction. In an article entitled, "Effects of Cell Phone <span class="blsp-spelling-error" id="SPELLING_ERROR_1">Radiofrequency</span> Signal Exposure on Brain Glucose Metabolism," the authors report that cell phone usage alters brain glucose metabolism.<div><br /></div><div>The study was conducted at <span class="blsp-spelling-error" id="SPELLING_ERROR_2">Brookhaven</span> National Laboratory. Forty seven healthy volunteers participated. Each person had a PET scan before and then after a 50 minute recorded conversation (with the sound muted so that auditory activation was not imaged by the PET scan). The authors found that brain regions nearest the cell phone antenna displayed significantly higher glucose metabolism after the 50 minute phone call.</div><div><br /></div><div>The authors concluded that the finding is of unknown clinical significance.</div><div><br /></div><div>The second update comes from the journal, <span class="blsp-spelling-error" id="SPELLING_ERROR_3">Bioelectromagnetics</span> (January 28, 2011). This study, entitled, "Time Trends (1998-2007)in Brain Cancer Incidence Rates in Relation to Mobile Phone Use in England," reviewed age group specific national cancer incidence rates in the United Kingdom. The authors found no statistically significant change in the incidence of brain cancer among men and women.</div><div><br /></div><div>The authors conclude that despite a dramatic increase in cell phone usage between the years 1998 and 2007, there has been no particular change in the incidence of brain cancer in the United Kingdom. The authors do not recommend any intervention to limit cell phone usage at this time.</div><div><br /></div><div>Until there is definitive data regarding the relationship between cell phone use and brain tumor formation, it is prudent to limit cell phone usage particularly among children with developing brains. </div><div><br /></div><div>We will continue to post new information on this blog as it becomes available.</div><div><br /></div><div><br /></div><div><br /></div><div><br /></div>RARhttp://www.blogger.com/profile/04647511597212113412noreply@blogger.com0tag:blogger.com,1999:blog-4065958629843931797.post-46841558307497827292010-11-29T14:07:00.004-05:002010-11-29T14:33:46.987-05:00Even More on Cell Phones and Brain Tumors<a onblur="try {parent.deselectBloggerImageGracefully();} catch(e) {}" href="https://blogger.googleusercontent.com/img/b/R29vZ2xl/AVvXsEj2ZwB1UB3VwA_RngY4eNenl9Id1qhv_bG5QvO32gez9mSqwsOgKzPhRY4nSuaS5UG2CgUXQlfhdbDEilsbxhdaPDLVOCexOrHd-QN3zhHK7EYtNYK5-b_3yrZFg1u9ryH81FfznQrReMsF/s1600/Screen+shot+2010-11-29+at+2.08.10+PM.png"><img style="display:block; margin:0px auto 10px; text-align:center;cursor:pointer; cursor:hand;width: 320px; height: 75px;" src="https://blogger.googleusercontent.com/img/b/R29vZ2xl/AVvXsEj2ZwB1UB3VwA_RngY4eNenl9Id1qhv_bG5QvO32gez9mSqwsOgKzPhRY4nSuaS5UG2CgUXQlfhdbDEilsbxhdaPDLVOCexOrHd-QN3zhHK7EYtNYK5-b_3yrZFg1u9ryH81FfznQrReMsF/s320/Screen+shot+2010-11-29+at+2.08.10+PM.png" border="0" alt="" id="BLOGGER_PHOTO_ID_5545050899555947426" /></a>This article appeared recently in the J<span class="Apple-style-span" style="white-space: pre-wrap; "><span class="blsp-spelling-error" id="SPELLING_ERROR_0">ournal</span> of C</span><span class="Apple-style-span" style="white-space: pre-wrap; "><span class="blsp-spelling-error" id="SPELLING_ERROR_1">omputer</span> Assisted Tomography. The authors conducted a review of published studies looking at long term (10 years or more) cell phone use and incidence of brain tumor. They particularly commented on two recent large studies: The <span class="blsp-spelling-error" id="SPELLING_ERROR_2">Interphone</span> Study, a multinational study, and Swedish studies lead by Dr. <span class="blsp-spelling-error" id="SPELLING_ERROR_3">Hardell</span>. The two studies have methodology issues. An important issue for the <span class="blsp-spelling-error" id="SPELLING_ERROR_4">Interphone</span> Study is that is was largely funded by mobile phone industry.</span><div><span class="Apple-style-span" style="white-space: pre-wrap; "><br /></span></div><div><span class="Apple-style-span" style="white-space: pre-wrap; ">Here are some interesting comments and conclusions:</span></div><div><ol><li><span class="Apple-style-span" style="white-space: pre-wrap;">Long-term cell phone use can increase the likelihood of being hospitalized for migraines and vertigo by 10% to 20%</span></li><li><span class="Apple-style-span" style="white-space: pre-wrap;">Cell phone storage in front pockets has been linked to poor fer<span class="blsp-spelling-error" id="SPELLING_ERROR_5">tility</span> and an increased chance of miscarriage and childhood cancer.</span></li><li><span class="Apple-style-span" style="white-space: pre-wrap;">Electromagnetic radiation from a cell phone can penetrate the skull and deposit energy 4 to 6 cm into the brain. This</span></li><li><span class="Apple-style-span" style="white-space: pre-wrap; "><b>long-term cell phone use can approximately double the risk of developing a <span class="blsp-spelling-error" id="SPELLING_ERROR_6">glioma</span> or an acoustic <span class="blsp-spelling-error" id="SPELLING_ERROR_7">neuroma</span> in the more exposed brain hemisphere (the side of most cell phone use)</b></span></li><li><span class="Apple-style-span" style="white-space: pre-wrap;">A study reported an 80% increased near significant risk (93.9%) of testicular cancer when the cell phone was kept in the left pocket, then the left testicle developed cancer; and kept in the right pocket, then the right testicle developed cancer</span></li></ol><span class="Apple-style-span" style="white-space: pre-wrap;">These are precautionary tips from the authors:</span></div><div><span class="Apple-style-span" style="white-space: pre-wrap;">"Here are some steps one can take to reduce exposure to electromagnetic energy from cell phones: </span></div><div><span class="Apple-style-span" style="white-space: pre-wrap;">1. Limit the use of cell phones to essential calls and keep calls short. 2. Children should be allowed to use a cell phone in cases of emergency only. Because of their developing skulls, the radiation can penetrate much more deeply. 3. Wear an air tube headset (not regular wired headset). The regular wired headset has been found to intensify radiation into the ear canal. The wire not only transmits the radiation from the cell phone but also serves as an an<span class="blsp-spelling-error" id="SPELLING_ERROR_8">tenna</span>, attracting <span class="blsp-spelling-error" id="SPELLING_ERROR_9">EMFs</span> from the surroundings. 4. Do not put the cell phone in a pocket or a belt while in use or while it is on. The body tissue in the lower body area has good conductivity and absorbs radiation more quickly than the head. One study shows that men who wear cell phones near their groin could have their sperm count dropped by as much as 30%. 5. If using the phone without a headset, wait for the call to connect before placing the phone next to the ear. 6. Do not use the cell phone in enclosed metal spaces such as vehicles or elevators, where devices may use more power to establish connection. 7. Do not make a call when the signal strength is 1 bar or less, which means the phone must work harder to establish a connection.</span></div><div><span class="Apple-style-span" style="white-space: pre-wrap;">8. Use a scientifically validated EMF protection device. There are advanced technologies available nowadays that strengthen the <span class="blsp-spelling-error" id="SPELLING_ERROR_10">bioenergy</span> field and immune system against the effects of EMF. 9. Use text instead of talk. </span></div><div><span class="Apple-style-span" style="white-space: pre-wrap;">10. Use landlines. </span></div><div><span class="Apple-style-span" style="white-space: pre-wrap;">11. Keep cell phone off most of the time. Let people leave messages and then call them back from a <span class="blsp-spelling-error" id="SPELLING_ERROR_11">landline</span>. </span></div><div><span class="Apple-style-span" style="white-space: pre-wrap;">12. Limit the use of cell phones in rural areas."</span></div><div><span class="Apple-style-span" style="white-space: pre-wrap;"><br /></span></div><div><span class="Apple-style-span" style="white-space: pre-wrap;">So, evidence is mounting that there are health concerns related to long term cell phone use. It seems prudent to limit cell phone use especially for young children.</span></div>RARhttp://www.blogger.com/profile/04647511597212113412noreply@blogger.com0tag:blogger.com,1999:blog-4065958629843931797.post-48937803159670205612010-10-07T19:42:00.003-04:002010-10-07T20:54:33.273-04:00Brain Tumor VaccinesIn the recent weeks, there has been a lot of media attention given to brain tumor vaccines. In this post, the two of the more publicized vaccines will be reviewed. First, though, a bit about the immune system and the effects of cancer.<br /><ol><li><span style="font-style: italic;">Cancer and the Immune System</span>. Our immune system recognizes cells by their surface proteins, and can distinguish between cells that are supposed to be in our body and cells that are foreign (for example, transplanted organs) or cells that are infected with a virus. When our immune system recognizes a cell as foreign or infected, it has ways to eliminate those cells. Even though cancer cells have unusual surface proteins (due to mutation, for example), the cancer cell has developed complicated methods to avoid elimination by our immune system.</li><li><span style="font-style: italic;">Immunology 101</span>. For our purposes, there are three main types of cells in the immune system: T cells, B cells, and dendritic cells. T cells can recognize foreign cells or infected cells and can actually seek them out and destroy them. B cells produce antibodies that help guard against infectious diseases. Dendritic cells are also known as antigen presenting cells and are critically important in immune recognition of foreign cells and proteins. Dendritic cells actually take up bits and pieces of proteins, shuttle them to their cell surface and present them to T and B cells. When dendritic cells present foreign proteins from either transplanted cells or virus, for example, to T or B cells, the immune response is triggered. For many reasons, this does not happen properly in people with cancer.</li><li><span style="font-style: italic;">The brain tumor vaccine concept</span>. The thinking is that the immune system can be triggered to attack a cancer cell if the dendritic cell is primed with abundant cancer cell proteins. The dendritic cell is primed by injecting various forms of cancer proteins into the patient. The patient's own dendritic cells ingest this cancer protein, present it to T and B cells which then jump into action to find the cells bearing those cancer proteins on their surface.</li><li><span style="font-style: italic;">Oncophage vaccine</span>. This vaccine is manufactured from the patient's own glioblastoma (GBM) tissue. At surgery, a portion of the tumor tissue removed is specially packaged and sent to a company called Antigenics in Massachusetts. Antigenics purifies a protein cocktail from the tumor tissue, especially containing the key protein called heat shock protein gp96. The vaccine, called Oncophage, is prepared and sent back to the treating physician. The patient receives the vaccine through an injection every week or two. Right now, the vaccine is not for general release, it still has to go through additional clinical trial evaluation. There are currently two Phase II clinical trials, both led by Neurosurgeon Andrew Parsa at the University of California in San Francisco. One trial is for patients with newly diagnosed GBM, the second is for patients with recurrent GBM.</li><li><span style="font-style: italic;">EGFRvIII vaccine</span>. EGFR stands for epidermal growth factor receptor and it is a normal cell surface protein. In about one third of patients with GBM, their tumors have a mutated form of EGFR, called variant III or vIII. EGFRvIII is turned on all the time as opposed to normal EGFR that is turned on only when a particular chemical binds to it. In patients with GBM positive for the EGFRvIII mutation, a vaccine containing a portion of the EGFRvIII protein is given through an injection. The bits of EGFRvIII protein are ingested by dendritic cells, which in turn, activate T cells so that they will seek out and destroy tumor cells with EGFRvIII on the surface. Results from a Phase II clinical trial was recently reported. The main study sites were MD Anderson in Texas and Duke University in North Carolina. The study looked at 18 patients treated with vaccine and 17 patients treated in current standard fashion. The vaccinated patients had an average overall survival of 26.0 months compared to 15.0 months for the matched control group. That is statistically significant. The vaccine is called CDX-110 (Celldex) or Rindopepimut (Pfizer). A Phase III clinical trial will be needed prior to FDA approval.</li><li><span style="font-style: italic;">Conclusions</span>. The Oncophage vaccine is made from a patient's own tumor. The EGFRvIII vaccine is "off the shelf" and will only work in those patients with an EGFRvIII positive tumor. Though the results of clinical trial for both vaccine strategies are exciting, <span style="font-weight: bold;">please remember, only very small numbers of patients have been treated</span>, and Phase III clinical trials involving many hundreds of patients at a variety of centers will be required to determine if there is, in fact, significant benefit. These types of trials can take a long time to organize and complete.<br /></li></ol>RARhttp://www.blogger.com/profile/04647511597212113412noreply@blogger.com0tag:blogger.com,1999:blog-4065958629843931797.post-9852842294751142232010-07-28T21:08:00.004-04:002010-07-28T22:11:07.932-04:00More on Cell Phones and Brain TumorsTwo recently published studies on the usage of cell phones and the incidence of brain tumor reached conflicting conclusions.<div><br /></div><div>The first study, "<b>Association between number of cell phone contracts and brain tumor incidence in nineteen U.S. States</b>," authored by Steven Lehrer, Sheryl Green, and Richard G. Stock from Mount Sinai School Of Medicine, looked at the number of cell phone subscriptions and the number of brain tumors in 19 states. The authors found an independent correlation between cell phone subscriptions and brain tumor incidence and concluded, "<i>The very linear relationship between cell phone usage and brain tumor incidence is disturbing and certainly needs further epidemiological evaluation. In the meantime, it would be prudent to limit exposure to all sources of electro-magnetic radiation</i>."</div><div><br /></div><div>The second study, "<b>Brain cancer incidence trends in relation to cellular telephone use in the United States</b>," authored by Peter D. Inskip, Robert N. Hoover, and Susan S. Devesa from the National Institutes of Health, looked at brain tumor incidence rates from 1992 to 2006. Overall, there was a slightly downward trend except for 20-29 year old females. In this group of patients, there was a statistically significant increase in frontal lobe tumors--a region of the brain not felt to be at risk from cell phone use. The authors concluded, "<i>Overall,</i></div><div><i>these incidence data do not provide support to the view that cellular phone use causes brain cancer</i>."</div><div><br /></div><div>It is difficult to explain the opposing conclusions in these two studies. One issue in both studies is that if there is a causal relationship between cell phone use and brain tumors, it would take many years of cell phone use to yield a tumor. Because the remarkable increase in cell phone use is fairly recent, we may not know for another 10 or more years if there is a relationship between cell phones and brain tumors.</div><div><br /></div><div>In the meantime, it would be reasonable to use hands free technology and limit cell phone use in children and teens.</div>RARhttp://www.blogger.com/profile/04647511597212113412noreply@blogger.com0tag:blogger.com,1999:blog-4065958629843931797.post-35494631721821183322010-05-23T09:10:00.002-04:002010-05-23T09:44:21.158-04:00Do cell phones cause brain tumors?<a onblur="try {parent.deselectBloggerImageGracefully();} catch(e) {}" href="https://blogger.googleusercontent.com/img/b/R29vZ2xl/AVvXsEjdLHz-55OSz8AmCxYVs0WwFETV-6GNokXkyGtxKqHEEMo8C9TDng9025cZzyb9obXX1ZIvBRWshDeU50myxxG2tzhFhAOwo1XaoXoW2HVHx7xVDhHns7ZDWkfpm7twypSKTHb8GHq6RQdY/s1600/Screen+shot+2010-05-23+at+9.09.27+AM.png"><blockquote></blockquote><img style="display:block; margin:0px auto 10px; text-align:center;cursor:pointer; cursor:hand;width: 320px; height: 109px;" src="https://blogger.googleusercontent.com/img/b/R29vZ2xl/AVvXsEjdLHz-55OSz8AmCxYVs0WwFETV-6GNokXkyGtxKqHEEMo8C9TDng9025cZzyb9obXX1ZIvBRWshDeU50myxxG2tzhFhAOwo1XaoXoW2HVHx7xVDhHns7ZDWkfpm7twypSKTHb8GHq6RQdY/s320/Screen+shot+2010-05-23+at+9.09.27+AM.png" border="0" alt="" id="BLOGGER_PHOTO_ID_5474452493063346450" /></a><br />Simple answer: <b><i><span class="Apple-style-span" style="color:#FF6600;">we still don't know</span></i></b>. <div><br /></div><div>The results from the INTERPHONE study were published in the May issue of the International Journal of Epidemiology. This is the world's largest study on cell phone use and brain tumors. The INTERPHONE study's main goal was "to determine whether mobile phone use increases the risk of brain tumors and, specifically, whether radiofrequency energy emitted by mobile phones is tumorigenic." </div><div>An additional question addressed was: "do mobile phones increase the risk of brain tumors within the first 10-15 years of use?"</div><div><br /></div><div>Unfortunately, due to methods, biases inherent in any epidemiology study of this magnitude, changes in mobile phone usage patterns and technology, <b><i>no clear conclusions can be drawn from this study.</i></b></div><div><br /></div><div>The International Agency for Research on Cancer (IARC) sponsored this multicenter study among 13 nations.</div><div><br /></div><div>The INTERPHONE study is a case control study. Investigators first identified cases of meningioma and glioma between 2000 and 2004. There were 2708 glioma patients and 2409 meningioma patients studied. A "matched" control patient was identified for each tumor patient. That is a patient without a brain tumor who was of the same sex, approximately the same age, and from the same geographic region. There were 2972 matched controls for the glioma group and 2662 for the meningioma group. </div><div><br /></div><div>During face to face interviews, all participants were questioned in detail about their past cell phone use. If the patient had died or was too ill to be interviewed, a "proxy" was interviewed.</div><div><br /></div><div>As you can see, the results are completely dependent on a person's precise recall of past cell phone use and may not be entirely accurate.</div><div><br /></div><div>Additional data analysis is ongoing and a large, prospective study is underway. So for now, no specific guidelines can be given regarding cell phone use and brain tumor. </div><div><br /></div><div><ul><li>However, common sense would tell us to limit a child's usage, use speaker phone and hands free methods, use text messaging (<i>but not while driving</i>), and don't always listen with the same ear.</li></ul></div><div><br /></div><div><br /><div><br /></div></div>RARhttp://www.blogger.com/profile/04647511597212113412noreply@blogger.com0tag:blogger.com,1999:blog-4065958629843931797.post-46800806880540768952010-05-13T11:00:00.008-04:002010-05-13T11:46:52.475-04:002010 Karry Award Winners<a onblur="try {parent.deselectBloggerImageGracefully();} catch(e) {}" href="https://blogger.googleusercontent.com/img/b/R29vZ2xl/AVvXsEil1HK_jY0PAkFaCkT-2jofiukDIqs3PT-SUFfMtciLqR-SfJj4Hjuf6pnBrBjPvIcarEBTGOqCNVLB8TQFu5AGt0Xh4LTJme0_NHN5Y-N51XxjAq3NnQ-Mw5rt1Tllm2F5cmp1EBGgNHGT/s1600/IMG_0503.JPG"><img style="float:right; margin:0 0 10px 10px;cursor:pointer; cursor:hand;width: 320px; height: 240px;" src="https://blogger.googleusercontent.com/img/b/R29vZ2xl/AVvXsEil1HK_jY0PAkFaCkT-2jofiukDIqs3PT-SUFfMtciLqR-SfJj4Hjuf6pnBrBjPvIcarEBTGOqCNVLB8TQFu5AGt0Xh4LTJme0_NHN5Y-N51XxjAq3NnQ-Mw5rt1Tllm2F5cmp1EBGgNHGT/s320/IMG_0503.JPG" border="0" alt="" id="BLOGGER_PHOTO_ID_5470779659939175682" /></a><br /><span class="Apple-style-span" style="font-family:verdana;">Congratulations to Ashley Tapio and her Lady Fishermen Varsity Basketball team for being chosen the 2010 Individual and Team Karry Award winners this year.</span><div><span class="Apple-style-span" style="font-family:verdana;"><br /></span></div><div><span class="Apple-style-span" style="font-family:verdana;">The John Karry Award is the highest honor bestowed by the UMBTC. It is named for John Karry. John completed the 40 mile bike ride on a heavy, old steel bike in the cold and damp of our inaugural Hope Starts Here Challenge. Two days later he was in the operating room undergoing his third operation for a recurrent malignant brain tumor. John's courage and spirit and never quit attitude inspired us then as it does now. The Karry award is given to the individual and team/group that most inspires our patients, families and staff.</span></div><div><span class="Apple-style-span" style="font-family:verdana;"><br /></span></div><div><span class="Apple-style-span" style="font-family:verdana;">Ashley Tapio is a senior at Ilwaco Highschool in Washington state and captain of her basketball team. Her grandmother, Phyllis Kuusisto, lives in the Keweenaw. In 2009, Phyllis was diagnosed with a glioblastoma multiforme (GBM). Ashley knew instantly that for her senior project she would honor her grandmother by raising funds and awareness for brain cancer research and treatment.</span></div><div><span class="Apple-style-span" style="font-family:verdana;"><br /></span></div><div><span class="Apple-style-span" style="font-family:verdana;">Her mentor for this project was Ned Bittner, Head Coach of the Lady Fishermen Varsity Basketball team. Ned was eager to help as his mother-in-law, </span><span class="Apple-style-span" style="font-size:medium;"><span class="Apple-style-span" style="font-family:verdana;">Linda Cheuvront, was battling brain cancer also.</span></span></div><div><span class="Apple-style-span" style="font-size:medium;"><span class="Apple-style-span" style="font-family:verdana;"><br /></span></span></div><div><span class="Apple-style-span" style="font-size:medium;"><span class="Apple-style-span" style="font-family:verdana;">During the '09-10 season, Ashley and her team wore special t-shirts, and there were announcements and banners throughout their highschool. Ashley also organized a 2nd through 6th grade girl's basketball camp, Hoops for Brain Cancer. </span></span></div><div><span class="Apple-style-span" style="font-size:medium;"><span class="Apple-style-span" style="font-family:verdana;"><br /></span></span></div><div><span class="Apple-style-span" style="font-size:medium;"><span class="Apple-style-span" style="font-family:verdana;">Through her efforts and the generosity of the Ilwaco community, Ashley raised over $700.00 for the UMBTC.</span></span></div><div><span class="Apple-style-span" style="font-size:medium;"><span class="Apple-style-span" style="font-family:verdana;"><br /></span></span></div><div><span class="Apple-style-span" style="font-size:medium;"><span class="Apple-style-span" style="font-family:verdana;">We are very proud of Ashley and her team for their very extraordinary support of Phyllis, Linda and the UMBTC. And we hope that the Hoops for Brain Cancer basketball camp continues and grows for many years to come.</span></span></div><div><span class="Apple-style-span" style="font-size:medium;"><span class="Apple-style-span" style="font-family:verdana;"><br /></span></span></div><div><span class="Apple-style-span" style="font-size:medium;"><span class="Apple-style-span" style="font-family:verdana;">In the photos, you will see Ashley and her grandmother Phyllis, her team and Hoops for Brain Cancer participants and coaches.</span></span></div><div><span class="Apple-style-span" style="font-family:'times new roman', 'new york', times, serif;"><span class="Apple-style-span" style="font-size:medium;"><br /><br /><a onblur="try {parent.deselectBloggerImageGracefully();} catch(e) {}" href="https://blogger.googleusercontent.com/img/b/R29vZ2xl/AVvXsEg2PD9_2uSpqpBxXnWi9MS7iaNP4a-FxHzqGGnbY9HnCyoHxYXr6AHvxhp5eeiNpqeS886lB2j2aYrKYCODCCHtkKVWUghf2vSGaRDTuHntYrfkFsAhTNbgWkQvJw8B4GapcA096P9A9Wlk/s1600/PC258255.JPG"><img style="cursor:pointer; cursor:hand;width: 240px; height: 320px;" src="https://blogger.googleusercontent.com/img/b/R29vZ2xl/AVvXsEg2PD9_2uSpqpBxXnWi9MS7iaNP4a-FxHzqGGnbY9HnCyoHxYXr6AHvxhp5eeiNpqeS886lB2j2aYrKYCODCCHtkKVWUghf2vSGaRDTuHntYrfkFsAhTNbgWkQvJw8B4GapcA096P9A9Wlk/s320/PC258255.JPG" border="0" alt="" id="BLOGGER_PHOTO_ID_5470778410523020178" /></a> </span></span></div><img style="float:left; margin:0 10px 10px 0;cursor:pointer; cursor:hand;width: 320px; height: 240px;" src="https://blogger.googleusercontent.com/img/b/R29vZ2xl/AVvXsEgcp-eunbUET7G_avmILdgLs1O4pr145wKQ_0pk_gTTn5ll1aCKPBnyon9w16sFQ9sWm_G09qyPePBKekTNRg9fMp0lpVEjI3tC3-qHPwg8uYmhGSgRPRgV1hV-9TU50smBTJspf3C10yck/s320/P2140416.JPG" border="0" alt="" id="BLOGGER_PHOTO_ID_5470780011078645266" /><img style="display:block; margin:0px auto 10px; text-align:center;cursor:pointer; cursor:hand;width: 320px; height: 228px;" src="https://blogger.googleusercontent.com/img/b/R29vZ2xl/AVvXsEitgwbRA-2_rlRHlkWtgQfcx9b_mwmHCR6tJbhOy3j7ghs970eXn1rSRKlfHSlz4shM8voz1tK53Nyxg01WZQgUUK2B1GH3sNWd6qvQz7NUR9XHyBs_pC_jeyXmTvDsgi_gXPEEGKOXxwaH/s320/2010-05-11-1207-56_edited.jpg" border="0" alt="" id="BLOGGER_PHOTO_ID_5470779042617172338" /><div style="text-align: center;"><br /></div>RARhttp://www.blogger.com/profile/04647511597212113412noreply@blogger.com0tag:blogger.com,1999:blog-4065958629843931797.post-79531458029595857162010-05-11T08:31:00.003-04:002010-05-11T09:23:35.724-04:005th Annual Hope Starts Here ChallengeFor the second year in a row, nasty weather descended on the UP, but it did not dampen the outpouring of support for the event. And for the second year in a row, we shattered participation numbers. There were about 330 registered for this year's event--including 50 people who signed up the morning of the Challenge, despite several inches of snow and a winter storm warning.<div><br /></div><div>First, a truly heartfelt thanks to all who participated in, volunteered at, or sponsored the event. While the funds raised are vitally important to maintain and expand the UMBTC's programs, equally important is the inspiration and motivation your support provides to our patients, families and staff.</div><div><br /></div><div>It is a little crazy, though, that the worse the weather, the better the turnout. I think that really speaks to the character of the folks that live in the UP. We embrace a cause because it is important and we embrace our weather because it sets us apart, makes us stronger.</div><div><br /></div><div>What is it about the Hope Starts Here Challenge and the UMBTC that gets people out of a nice warm bed to face a cold, snowy morning? I think it is because all our programs are centered around our patients and families. I think it is because all our members are enthusiastic, energetic and hopeful. I think it is because we are always moving forward, open to new approaches and new ideas. I think it is because the things we learn caring for our brain tumor patients can be applied to caring for patients with other cancers. </div><div><br /></div><div>Thank you for your support. See you next May for the 6th Annual Hope Starts Here Challenge.</div>RARhttp://www.blogger.com/profile/04647511597212113412noreply@blogger.com1tag:blogger.com,1999:blog-4065958629843931797.post-81832371049609502722010-05-06T18:51:00.004-04:002010-05-06T20:35:35.238-04:00Do snow clouds have silver linings?Yes. For sure. <div>Some of you may be watching the weather forecast for May 8, the date for the 5th Annual Hope Starts Here Challenge. If you haven't seen it, here it is: </div><div><br /></div><a onblur="try {parent.deselectBloggerImageGracefully();} catch(e) {}" href="https://blogger.googleusercontent.com/img/b/R29vZ2xl/AVvXsEhIkDchd4qo3LsnUdp7ijZNpAR-OOhQkSJhL67CLiWO5_cFJ8IlIDJa9mts5nYCKG0fWw6kXNu-RGCrBQ3q257hNIIapMQguOJt3HOFhbK2ozUS2pVU6unD9p5q57AH933pfixOuSKamEvI/s1600/Screen+shot+2010-05-06+at+7.00.53+PM.png"><img id="BLOGGER_PHOTO_ID_5468296091713716242" style="DISPLAY: block; MARGIN: 0px auto 10px; WIDTH: 320px; CURSOR: hand; HEIGHT: 183px; TEXT-ALIGN: center" alt="" src="https://blogger.googleusercontent.com/img/b/R29vZ2xl/AVvXsEhIkDchd4qo3LsnUdp7ijZNpAR-OOhQkSJhL67CLiWO5_cFJ8IlIDJa9mts5nYCKG0fWw6kXNu-RGCrBQ3q257hNIIapMQguOJt3HOFhbK2ozUS2pVU6unD9p5q57AH933pfixOuSKamEvI/s320/Screen+shot+2010-05-06+at+7.00.53+PM.png" border="0" /></a> <div>Sounds nasty. It is hard for me to believe that the weather for this year's event could be worse than the wind driven shards of ice we rode through last year. It is also hard to believe May 8th could see worse winter weather than March 8th.</div><div><br /></div><div>Maybe, the forecast will be wrong.</div><div><br /></div><div>Even if the weatherman is right, I will be at MGH and I hope you will be too. Even if I can't ride because of snow, I will be there. I might run or maybe walk, but I will be there. Smiling. Enjoying the warm companionship of my family and friends.</div><div><br /></div><div>Why? Because every once in a while it is important to be part of something bigger than yourself: showing our support for patients and families during Brain Tumor Awareness Month, for example. </div><div><br /></div><div>There is another reason to get out of your cozy, warm bed and get dressed in layers to ride your bike, or walk or run: every once in a while we need to do something outside our comfort zone. When we challenge ourselves in this way, we can get an appreciation for the strength and resolve our brain tumor patients and families display everyday. </div><div><br /></div><div>If we can meet this challenge, just think what else we can do.</div><div><br /></div><div>So, come Saturday, get out your hats and gloves and snowpants, come on over to MGH and be part of something extraordinary and memorable.</div><div><br /></div><div>And the silver lining? We could always build snowmen.</div>RARhttp://www.blogger.com/profile/04647511597212113412noreply@blogger.com0tag:blogger.com,1999:blog-4065958629843931797.post-89430935171466077822010-04-28T12:48:00.002-04:002010-04-28T13:12:28.151-04:00Graduate Student Research at UMBTCThe research lab and graduate and undergraduate student education has been and is a top priority for the UMBTC. The UMBTC provides an opportunity for students to learn, contribute and excel. We have been fortunate to work with bright, talented and motivated students. This year, the tradition of excellence continues. I am pleased to report that for the third year running, one of our graduate students took first place honors at the Celebration of Student Research, April 15th at NMU. And for the second time in three years, our students place 1st and 2nd.<div><br /></div><div>Danny LeBert received the top prize for his research, "Investigation of an Alternative Cancer Recurrence Model and Characterization of Murine Neural Stem Cell Migratory Capabilities." This work aims to determine the mechanisms that lead to GBM recurrence. Danny will defend his Master's thesis this summer and will hopefully complete a postgraduate year in our lab.</div><div><br /></div><div>Vanessa Thibado came in a close second with her work, "PARP-1 Inhibition as Concomitant Therapy in Resistant Glioblastoma Multiforme." This work is evaluating alternative treatment targets to render GBM more sensitive to chemotherapy. Vanessa is completing her first graduate year and will continue her work over the summer and the next academic year.</div><div><br /></div><div>Danny and Vanessa are also very active in the Graduate Student Association at NMU. Vanessa is currently serving as President. She and Danny travelled to Lansing as Ambassadors to the 2010 Michigan Graduate Education Day. They were the only two graduate students from NMU to attend. Overall, 71 grad students from 16 Michigan universities participated. Danny and Vanessa met with Steve Lindberg, State Representative for our district and were introduced by him to the State House of Representatives.</div><div><br /></div><div>These opportunities are made possible through the generous support of our community to the UMBTC. </div><div><br /></div><div>On May 8th, the UMBTC is hosting its once a year fundraising event, the Hope Starts Here Challenge. We'd love for you to participate and, if possible, make a tax deductible contribution to the UMBTC so that we can continue the programs that are making a difference in the lives of our patients and families.</div>RARhttp://www.blogger.com/profile/04647511597212113412noreply@blogger.com0tag:blogger.com,1999:blog-4065958629843931797.post-44319336605587075022010-04-26T18:43:00.002-04:002010-04-26T18:51:06.043-04:00National Brain Tumor Society launches a new online community<a onblur="try {parent.deselectBloggerImageGracefully();} catch(e) {}" href="https://blogger.googleusercontent.com/img/b/R29vZ2xl/AVvXsEil9AuNdAeYppzcW1IApy1vSosDuimlPtBsQgKAQhjbIUClgzPDCpHN9eyTyz9mCPLwiGRqyFdP96h2_RkMByLhYlVbgRFrbe8a1t8lLXeif8wGP1GRG5thVeVwwFglIENo652IVljDL9tn/s1600/Screen+shot+2010-04-26+at+6.43.08+PM.png"><img style="display:block; margin:0px auto 10px; text-align:center;cursor:pointer; cursor:hand;width: 320px; height: 268px;" src="https://blogger.googleusercontent.com/img/b/R29vZ2xl/AVvXsEil9AuNdAeYppzcW1IApy1vSosDuimlPtBsQgKAQhjbIUClgzPDCpHN9eyTyz9mCPLwiGRqyFdP96h2_RkMByLhYlVbgRFrbe8a1t8lLXeif8wGP1GRG5thVeVwwFglIENo652IVljDL9tn/s320/Screen+shot+2010-04-26+at+6.43.08+PM.png" border="0" alt="" id="BLOGGER_PHOTO_ID_5464582239138740514" /></a><br />The National Brain Tumor Society has created an online community called My.BrainTumorCommunity.org. Similar to the social networking opportunities provided by the UMBTC (Facebook, Blog, Twitter), My.BrainTumorCommunity is a moderated space that "allows visitors to get helpful information, ask questions, lend support, build friendships." The site is available 24/7 and features blogs, discussion forums and photo sharing.<div>Check the site out and let us know what you think.<br /> <div><br /></div></div>RARhttp://www.blogger.com/profile/04647511597212113412noreply@blogger.com0tag:blogger.com,1999:blog-4065958629843931797.post-47650726765774035692010-04-14T21:33:00.010-04:002010-04-14T22:22:23.078-04:00The 2010 Hope Starts Here Challenge Jerseys Are Here!<a onblur="try {parent.deselectBloggerImageGracefully();} catch(e) {}" href="https://blogger.googleusercontent.com/img/b/R29vZ2xl/AVvXsEi4rKIg7S5c6bspAhbqNkT-LvXyV7Yrpe-w_IYv65WC1JqACXe3x5YEa9y_p6WHCILUhpxfHFIdmhfgdZVqtoaJ-D8N3Fe2fp1I9vXReiFUVteeXki9bSHpuoZdyTw9oHxcBPCEf4vSjunZ/s1600/_IGP0061+-+Version+2.jpg"><img style="float:right; margin:0 0 10px 10px;cursor:pointer; cursor:hand;width: 213px; height: 320px;" src="https://blogger.googleusercontent.com/img/b/R29vZ2xl/AVvXsEi4rKIg7S5c6bspAhbqNkT-LvXyV7Yrpe-w_IYv65WC1JqACXe3x5YEa9y_p6WHCILUhpxfHFIdmhfgdZVqtoaJ-D8N3Fe2fp1I9vXReiFUVteeXki9bSHpuoZdyTw9oHxcBPCEf4vSjunZ/s320/_IGP0061+-+Version+2.jpg" border="0" alt="" id="BLOGGER_PHOTO_ID_5460173744241435410" /></a><br /><a onblur="try {parent.deselectBloggerImageGracefully();} catch(e) {}" href="https://blogger.googleusercontent.com/img/b/R29vZ2xl/AVvXsEjG_1uNIB8SmVgfGepNDz3r4B4wpTF_hpG2hcvRNPYg2ccH5_at5A4q0IqnIPaBdVS55SbOnNkJ5ur7ZkN780BAX0v3k_bXTzFmWQNY44VQv4EFjngUaFZDa-nbxVaZf5HfXBxw55w2wnXT/s1600/_IGP0064+-+Version+2.jpg"><img style="float:left; margin:0 10px 10px 0;cursor:pointer; cursor:hand;width: 213px; height: 320px;" src="https://blogger.googleusercontent.com/img/b/R29vZ2xl/AVvXsEjG_1uNIB8SmVgfGepNDz3r4B4wpTF_hpG2hcvRNPYg2ccH5_at5A4q0IqnIPaBdVS55SbOnNkJ5ur7ZkN780BAX0v3k_bXTzFmWQNY44VQv4EFjngUaFZDa-nbxVaZf5HfXBxw55w2wnXT/s320/_IGP0064+-+Version+2.jpg" border="0" alt="" id="BLOGGER_PHOTO_ID_5460173567192828354" /></a><br /><br />The much anticipated Hope Starts Here Jerseys are here. They are perfect for running, cycling or walking. <div>Now, the jersey may not make you faster or smarter, or help you find your soulmate*, but by owning this jersey, you can show your support for all the patients and families dealing with brain tumors. <div>The unisex jersey is $50.00, with every penny raised used to fund research to find better treatments and improve quality of life for our brain tumor patients.</div><div>These jerseys will be sold at the Challenge on May 8. If you want to get your hands on one sooner, visit the Down Wind Sports booth at the Rec show this weekend at Lakeview.</div><div><br /><div>A special thanks to our models. Samantha is an RN and works in the ICU at Marquette General. She cares for many of our brain tumor patients right after surgery. Samantha is also studying quality of life issues affecting brain tumor patients. </div><div>Brett is a personal trainer and owner of B Cubed Fitness (906-869-4990). Brett specializes in applied functional science techniques for evaluation, training, and rehabilitation. Both Samantha and Brett will be at the Challenge, and would be happy to talk with you.</div><div><br /></div><div>*Well, maybe the jersey does help you find your soulmate...Congratulations to Brett and Samantha on their engagement!</div></div></div><br /><br /><img style="cursor:pointer; cursor:hand;width: 253px; height: 320px;" src="https://blogger.googleusercontent.com/img/b/R29vZ2xl/AVvXsEh6IJklk9BnIam767JzLyzFk5DYeNuQW1B1lWr9-lPYOq68wHR044MiV4WxxcfAqXlHoI6ozVPnzjJkg5mRk8KATeMj2_DQELAIFgAl8itUEEeJMLqc9Ny124x6wTmFEX9eAz4CST7e6qOl/s320/_IGP0072+-+Version+2.jpg" border="0" alt="" id="BLOGGER_PHOTO_ID_5460179633965121570" /><a onblur="try {parent.deselectBloggerImageGracefully();} catch(e) {}" href="https://blogger.googleusercontent.com/img/b/R29vZ2xl/AVvXsEhGX0y3lrx483th40bMQ_u_2dbQWrqUNhiexeyFtBouEZ0caYBNG6mBILC0Ow9ErHC0HwbmewF0fkB12oOoP_v_obqiO-rO90WtMiLgGKgsVFLoaqUENt6BX3xRf_yCQjzUkLxxMUmfw3kk/s1600/_IGP0066+-+Version+2.jpg"><img style="cursor:pointer; cursor:hand;width: 213px; height: 320px;" src="https://blogger.googleusercontent.com/img/b/R29vZ2xl/AVvXsEhGX0y3lrx483th40bMQ_u_2dbQWrqUNhiexeyFtBouEZ0caYBNG6mBILC0Ow9ErHC0HwbmewF0fkB12oOoP_v_obqiO-rO90WtMiLgGKgsVFLoaqUENt6BX3xRf_yCQjzUkLxxMUmfw3kk/s320/_IGP0066+-+Version+2.jpg" border="0" alt="" id="BLOGGER_PHOTO_ID_5460179627251306354" /></a>RARhttp://www.blogger.com/profile/04647511597212113412noreply@blogger.com0tag:blogger.com,1999:blog-4065958629843931797.post-59338054527485499012010-04-08T12:35:00.005-04:002010-04-08T12:57:57.887-04:00What do April Snow Showers Bring??Thirty days before the Hope Starts Here Challenge. I had planned a ride to preview the course, but awoke to a three inch blanket of newly fallen snow. Still, not as bad as last year's ride.<div>Happily, my bike needed fixing (thanks Down Wind Sports) so I was forced to take these videos from the car. </div><div>The first clip is at the ski hill looking up 553.</div><iframe allowfullscreen='allowfullscreen' webkitallowfullscreen='webkitallowfullscreen' mozallowfullscreen='mozallowfullscreen' width='320' height='266' src='https://www.blogger.com/video.g?token=AD6v5dx5qOTiRtNwXgTbJ34T3kWS5y9VjyUqM6CGRE7xP1znD1B1IhaYppwNvxXCvJvnJ-ydAQ78GqKvQx1GUVyiNQ' class='b-hbp-video b-uploaded' frameborder='0'></iframe><div>The second clip is on Lakeshore along Picnic Rocks.</div><iframe allowfullscreen='allowfullscreen' webkitallowfullscreen='webkitallowfullscreen' mozallowfullscreen='mozallowfullscreen' width='320' height='266' src='https://www.blogger.com/video.g?token=AD6v5dzxIFcz4lR5orTPQbLIkvPa0Y7jZXoopuPO4nycTKmGPQ2wGgeseQlWeN-CUxpTW4kZcqOINDmhtKy8dIM4UA' class='b-hbp-video b-uploaded' frameborder='0'></iframe><div>March 8th, was sunny and 50. April 8th, snowing and blowing. May 8th? I have no doubt that it will be a great day.<br /><div><br /></div></div>RARhttp://www.blogger.com/profile/04647511597212113412noreply@blogger.com0tag:blogger.com,1999:blog-4065958629843931797.post-9217794818869161962010-04-04T11:12:00.000-04:002010-04-04T11:22:57.187-04:00Endoscopic Removal of Pituitary TumorsNeurosurgeons at University of Cincinnati report that using the endoscope during pituitary tumor surgery results in a more complete resection. While a complete resection isn't always possible or even necessary, it is very helpful for patients with tumors that are secreting too much hormone. A complete resection lowers risk of recurrence and can lead to better normalization of pituitary hormone function. Follow this link for more details: http://www.google.com/gwt/x?oe=UTF-8&client=safari&u=http%3A%2F%2Fj.mp%2FaNxWDy<br /><br /><br />- Posted using BlogPress from my iPhone<br />RARhttp://www.blogger.com/profile/04647511597212113412noreply@blogger.com0tag:blogger.com,1999:blog-4065958629843931797.post-2868399789777920432010-04-03T14:38:00.005-04:002010-04-03T14:55:42.154-04:002010 Hope Starts Here Challenge Long Ride MapThe GPS mapped long ride route is now available. The course takes riders from Marquette General Hospital, along Lake Superior, then out to KI Sawyer airport. Please note, the turn around point/aid station will not be at the W as it was in years past. We are working on securing a new turn around point. The long ride (to be renamed the Airport Ride for next year--it sounds less intimidating) is 38.63 miles.<div><div><br /><img style="cursor:pointer; cursor:hand;width: 211px; height: 320px;" src="https://blogger.googleusercontent.com/img/b/R29vZ2xl/AVvXsEhCYdH91Tu53POBZ2SowsCYHSTKWcopj78py8Dc6oz9276VyuBYboX00UgIkQcKvwJO4ukPKdZFba-Yi4NOA2PrGhiPKkl3tcmH5D2mCDZ4KbVL2HCLYnodxZHsNgjXK8YCZ4HePZ8v_dko/s320/Screen+shot+2010-04-01+at+11.55.50+AM.png" border="0" alt="" id="BLOGGER_PHOTO_ID_5455983944312335426" /><img style="cursor:pointer; cursor:hand;width: 320px; height: 130px;" src="https://blogger.googleusercontent.com/img/b/R29vZ2xl/AVvXsEgAyCvxE4F7ko2_pt7vSmamzZRu-kJbdRmzbwnai3yRbNaAlOTBtEn4ll0rZ7SDomytMiDLaiAD-ESdMAbPumzO1hOFd6cs0ySCllxU1PT2Gfn7Yu3pBI4Yao_ELTmUwHE3HlnwbzC2Oo1R/s320/Screen+shot+2010-04-01+at+11.54.47+AM.png" border="0" alt="" id="BLOGGER_PHOTO_ID_5455983935352395810" /><img style="cursor:pointer; cursor:hand;width: 320px; height: 308px;" src="https://blogger.googleusercontent.com/img/b/R29vZ2xl/AVvXsEiQMYFGIzBYovB6BZ0DgIXE66zQJ01pXkG8LLz82g9YrOnxseG0mtHnj0I61i8rELBJyroPgpUuJ1VbUkH0AzmsrL50qGzSdK8CVBP7GnEyj4Pha2POci1kzgI4fe6ja2QsSHcX2zPtXjC-/s320/Screen+shot+2010-04-01+at+12.07.02+PM.png" border="0" alt="" id="BLOGGER_PHOTO_ID_5455983957443378818" /><img style="cursor:pointer; cursor:hand;width: 261px; height: 320px;" src="https://blogger.googleusercontent.com/img/b/R29vZ2xl/AVvXsEgmKELXudIVM9rlYa4feNRfyBykf54PvP1boDQPiU8wpy6I9dFRwWMToj1EIiz_SdFSlY3wloC-EbLkijG9c0tKtEa00KHQoQO1A9sCkHSnKjzslWfmuqAUdx52eCUVftHmb73dkxAnCjfj/s320/Screen+shot+2010-04-01+at+12.08.56+PM.png" border="0" alt="" id="BLOGGER_PHOTO_ID_5455983966889028178" /></div><div><br /><img style="cursor:pointer; cursor:hand;width: 218px; height: 320px;" src="https://blogger.googleusercontent.com/img/b/R29vZ2xl/AVvXsEgTnSm_Am-XqRw5JwDKnOA415UjtSw0ImOWKW4Gjbh9mHWIrW9N0RnbbusW9rcvvYuPbZaoNNXUa3HLiK0JK3s6f-EJgV8Ry9BhxaiipN4WtIVSaYMvexgZ5Iwctb3bjOL3lyoYyRjLl4R0/s320/Screen+shot+2010-04-01+at+12.09.30+PM.png" border="0" alt="" id="BLOGGER_PHOTO_ID_5455983975522544050" /><img style="cursor:pointer; cursor:hand;width: 229px; height: 320px;" src="https://blogger.googleusercontent.com/img/b/R29vZ2xl/AVvXsEj1s5sR4l7AZjowTIj5CIAh8os3QvD144OTm4cfCJf3voD7Yf2eujDXYDE8aeq1NybVhAMr7mKfq1f6fCjCe5hgrYzjkoZeke3C2Ag5XHxhQlPi_YWIsJsk6aFzJKwF5CKzbFG3xByswGaD/s320/Screen+shot+2010-04-01+at+12.10.20+PM.png" border="0" alt="" id="BLOGGER_PHOTO_ID_5455984168809900530" /><br /><br />The first map is the overall course. Next is the elevation profile--mostly downhill!! The other maps are zoomed views showing the route to/from the hospital along the Lake, crossing the high way at Beef-A-Roo, Division to 553, 553 to airport.</div><div><br /></div><div><br /><div><br /></div></div></div>RARhttp://www.blogger.com/profile/04647511597212113412noreply@blogger.com0tag:blogger.com,1999:blog-4065958629843931797.post-83402424826407445142010-03-31T18:01:00.003-04:002010-03-31T18:24:32.754-04:00Can a tomato plant provide a new treatment for GBM?<a onblur="try {parent.deselectBloggerImageGracefully();} catch(e) {}" href="https://blogger.googleusercontent.com/img/b/R29vZ2xl/AVvXsEiiueESeH7xWrDksZgxgppMQrPpemkfgK6CvUUtvvWlLUMqSGkIKjGptZ2Fr9U4M9WpnO6QpT8kRTLJJapg-SYvTluec2_uzkZV5dUVGrUokHXFw_UCPRYS6pgRja4I3R3IoWRtT-bQtkmu/s1600/Screen+shot+2010-03-31+at+6.03.40+PM.png"><img style="float:left; margin:0 10px 10px 0;cursor:pointer; cursor:hand;width: 320px; height: 182px;" src="https://blogger.googleusercontent.com/img/b/R29vZ2xl/AVvXsEiiueESeH7xWrDksZgxgppMQrPpemkfgK6CvUUtvvWlLUMqSGkIKjGptZ2Fr9U4M9WpnO6QpT8kRTLJJapg-SYvTluec2_uzkZV5dUVGrUokHXFw_UCPRYS6pgRja4I3R3IoWRtT-bQtkmu/s320/Screen+shot+2010-03-31+at+6.03.40+PM.png" border="0" alt="" id="BLOGGER_PHOTO_ID_5454922326165595346" /></a>This recently published paper from Stockholm inserted a gene from a tomato plant into GBM cells and made them more susceptible to treatment. <div><br /></div><div>How does this work?</div><div><br /></div><div>It is called suicide gene therapy. And this is the concept: find a gene coding for an enzyme that human cells don't have. Insert that gene only into cancer cells--not normal cells. This enzyme works by taking a harmless "pro-drug" and converting it into a toxic compound. Early attempts at this therapy used the enzyme thymidine kinase from the herpes simplex virus. This enzyme converts the drug ganciclovir into a compound that stops DNA synthesis. If a cancer cell can't make new DNA, it will eventually die.</div><div><br /></div><div>The current paper uses the thymidine kinase gene from the tomato plant. The gene is delivered to GBM cells by neural stem cells. The tomato thymidine kinase acts on the drug AZT and converts it into compounds that interfere with DNA synthesis. </div><div><br /></div><div>AZT might sound familiar. It is a retroviral agent used to treat patients with HIV. Jerome Horwitz first created the compound in 1964 while at the Karmanos Cancer Center in Detroit. The drug works by preventing the RNA of the HIV virus changing itself into DNA.</div><div><br /></div><div>While tomato gene therapy may or may not make it to clinical trial stage, it is important for you to know that throughout the world, creative and ingenious new treatments for GBM are being developed all the time.</div>RARhttp://www.blogger.com/profile/04647511597212113412noreply@blogger.com0tag:blogger.com,1999:blog-4065958629843931797.post-71555221634540596152010-03-28T13:03:00.005-04:002010-03-28T13:28:54.299-04:00American Cancer Society Explains the Benefit of Health Care Reform for Cancer PatientsHealth care reform is controversial. The recently signed legislation may not be perfect, but it does benefit cancer patients in the following ways:<br />1. insurance coverage for patients participating in clinical trials<br />2. removal of lifetime caps<br />3. insurers can no longer exclude children with pre existing conditions from their parents' policy<br />4. dependent children up to age 26 can remain on their parents' policy<br />5. closing the drug prescription gap in Medicare Part D. As more and more cancer drugs become available in oral form, the drugs have become less affordable for cancer patients. Beginning in 2010, seniors who fall in the "doughnut hole," or, spend between $2,700 and $6,154, will receive a $250 government subsidy to help cover the costs of their medication. By 2020, Medicare will cover 75 percent of drug costs in the "doughnut hole" for Medicare patients.<br />6. focus more on prevention and early detection by requiring all insurance plans to provide coverage for essential, evidence-based preventive measures with no additional co-pays<br /><br />The American Cancer Society's Cancer Action Network and the American Society of Clinical Oncologists will continue their strong advocacy on behalf of cancer patients. Both organizations have pledged to work with Congress to improve and extend this historic legislation.RARhttp://www.blogger.com/profile/04647511597212113412noreply@blogger.com0tag:blogger.com,1999:blog-4065958629843931797.post-90395312262122595412010-03-18T19:26:00.002-04:002010-03-18T19:56:20.003-04:00Hair Care UpdateDisclaimer: Even though I have given many haircuts, I am no hair care expert. And, the UMBTC is not endorsing the products described below--they are examples of alternatives to your usual daily shampoos and conditioners.<br /><br />Over the next few weeks, the UMBTC is rolling out its quality of life initiative. We want to work with you, our patients and families, and health care providers and other folks in the community to find answers to questions like, "How do I take care of my hair and scalp during brain tumor treatment?" We hope to chip away at the worries and anxieties that can get you down.<br /><br />So, about hair and scalp care. We turned to <strong>Julie Champion at Sisters Hair Co. 906-226-4090</strong>. It turns out there are a number of products to gently cleanse your hair and scalp and stimulate blood flow to the hair follicles. Julie recommends Eufora products as they are organic, US made and cruelty free.<br /><br />For hair and scalp damaged by surgery, radiation and chemotherapy, try Eufora's <strong>Pure Cleanse Shampoo</strong> and <strong>Urgent Repair Replenishing Treatment</strong>.<br /><br />Julie, and all the stylists at Sisters Hair Co, provide free hair and scalp care consultation for patients undergoing cancer treatment. <strong><em>Please</em></strong> call for an appointment, there may be a wait before they can get you scheduled.<br /><br />Sisters Hair Co. also provides wiggery services. If you can get in before your treatment starts, they can do wonders matching your normal hair. They recommend synthetic wigs for easy care.<br /><br />If you have suggestions, please feel free to leave a comment.<br /><br />You can also check with other area salons to see what other products and services are available.RARhttp://www.blogger.com/profile/04647511597212113412noreply@blogger.com0tag:blogger.com,1999:blog-4065958629843931797.post-29393796437439085682010-03-08T16:20:00.000-05:002010-03-08T16:31:37.443-05:002009 Hope Starts Here Challenge PhotosAs I walk outside in the bright sunshine and 50 degree day, I can't help but wonder if March 8th will be nicer than May 8th. <br />To refresh everyone's memory of last year's ride, I posted a few photos on the UMBTC fan page. <br />Better get out today for a run, ride or walk. Only 61 days to the 5th annual Hope Starts Here Challenge. <br /><br /><br />- Posted using BlogPress from my iPhone<br />RARhttp://www.blogger.com/profile/04647511597212113412noreply@blogger.com0tag:blogger.com,1999:blog-4065958629843931797.post-34829994530555098252010-03-07T19:10:00.002-05:002010-03-07T19:14:15.048-05:00Fan Page is hereJust look at the right column. You will see badges that link to our Twitter and Facebook Fan Page. Now you have three ways to stay connected and updated. Please use these resources to show your support for friends and families.<br />We hope to see you May 8th.RARhttp://www.blogger.com/profile/04647511597212113412noreply@blogger.com0tag:blogger.com,1999:blog-4065958629843931797.post-13128622030972987732010-03-07T14:50:00.002-05:002010-03-07T14:56:06.938-05:00Hope Starts Here Facebook Fan PageAs if Twitter and a Blog aren't enough, the UMBTC will soon be on Facebook. We are developing a Fan Page so that our message can get out to more people. We especially would like more people to participate in the upcoming 5th Annual Hope Starts Here Challenge on May 8th. Check back soon for more details.RARhttp://www.blogger.com/profile/04647511597212113412noreply@blogger.com0tag:blogger.com,1999:blog-4065958629843931797.post-71379680540161794512010-02-13T10:37:00.005-05:002010-02-13T13:58:03.007-05:00UMBTC ushers in the era of Endoscopic NeurosurgeryImagine being able to look inside the brain through a straw sized opening or to remove a skull base tumor through the nose. Endoscopic neurosurgery is a way to do just that.<br /><br />Many surgical specialties use endoscopes to look inside the body. Orthopedic surgeons can peer inside knee, shoulder and elbow joints. Urologists can see inside the bladder, and general surgeons routinely remove gall bladders through the laparoscope. <br /><br />The advantage of these endoscopic techniques is that they are minimally invasive, and provide an amazingly vivid picture of the anatomy.<br /><br />The application of endoscopy to Neurosurgery is not new. In fact Neurosurgeons in the early 1900s were using endoscopes designed by Urologists to look inside the fluid spaces within the brain termed ventricles. But it wasn’t until the last few years that equipment advances, imaging tools and a more detailed understanding of microscopic anatomy have made the endoscopic techniques safer.<br /><br />There are two main areas in which endoscopic techniques excel. The first is the treatment of problems within the ventricles. This might include the removal of cysts or tumors or the treatment of hydrocephalus. <br /><br />This first video shows highlights of a colloid cyst removal using the endoscope. A colloid cyst is a benign fluid filled cyst. It often grows in the opening that connects the lateral ventricles to the third ventricle (Foramen of Monro). This can cause a backup of fluid and increased pressure termed hydrocephalus. Removing the cyst reopens normal CSF flow pathways.<iframe allowfullscreen='allowfullscreen' webkitallowfullscreen='webkitallowfullscreen' mozallowfullscreen='mozallowfullscreen' width='320' height='266' src='https://www.blogger.com/video.g?token=AD6v5dzd9srnHkQ0Codl4RshperK8kMb3rGzTBKdMzbJPSB9fv0CAZh2BaQ2A7R_GoO4UWP8MlctEOXCOVdxG1rwtg' class='b-hbp-video b-uploaded' frameborder='0'></iframe><br /><br />Most of the patients with hydrocephalus do not have a colloid cyst. For those patients, the treatment is to place a shunt or tube that diverts the fluid from the ventricle to the abdomen. For some of these patients, a hole can be placed in the floor of the third ventricle. This allows the built up CSF in the ventricle to empty into the fluid spaces at the base of the brain where it can be absorbed. This procedure, called endoscopic third ventriculostomy (ETV) can relieve the hydrocephalus without the need for a permanent shunt tube. The second video shows highlights from an ETV procedure.<iframe allowfullscreen='allowfullscreen' webkitallowfullscreen='webkitallowfullscreen' mozallowfullscreen='mozallowfullscreen' width='320' height='266' src='https://www.blogger.com/video.g?token=AD6v5dxwCO8faytwMNPCmnbOxtY0GLpk6s_M-h-mA_JyiTGBVzj1-LslN51dvR6EL_KAElkC-7tJsTny6kC17mJ1Xg' class='b-hbp-video b-uploaded' frameborder='0'></iframe><br /><br />The other area where endoneurosurgery excels is in the treatment of tumors involving the base of the skull. This includes pituitary tumors and meningiomas. These tumors can be approached through the nose and removed using endoscopic technique. Often the approach is performed with the assistance of ENT surgeons because of their familiarity with sinus anatomy.<br /><br />Endoscopic neurosurgery offers advantages for both the Neurosurgeon and the patient: for the Neurosurgeon, the anatomy is displayed with rich detail and for patients, recovery is often easier and quicker compared to conventional surgical approaches.<br /><br />Both intraventricular surgical approaches and anterior skull base surgery can be performed at Marquette General Hospital. Please contact the UMBTC at 906-225-7739 if you have questions regarding these procedures or to schedule a consultation. Please remember that the videos show only brief highlights of the procedures, the actual procedures are longer than the videos.RARhttp://www.blogger.com/profile/04647511597212113412noreply@blogger.com0tag:blogger.com,1999:blog-4065958629843931797.post-57725063908988417992010-02-12T21:11:00.000-05:002010-02-12T21:11:38.098-05:00Hope Starts Here Challenge UpdateHere is the preliminary schedule of events for the 5th Annual Hope Starts Here Challenge, May 8th, 2010.<br />
<ul><li>Registration opens 8 AM</li>
<li>Long Ride Start 9 AM</li>
<li>Long Run Start 10 AM</li>
<li>Short Ride Start 10:30 AM</li>
<li>Walk Start 10:40 AM</li>
<li>Short Run Start 11 AM</li>
<li>Lunch Start 11:30 AM</li>
</ul><strong>All times Eastern.</strong><br />
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Website should be updated soon. We'll try to include course maps for the 5K and 15K run.<br />
<br />
Check out our new logo:<br />
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</div>RARhttp://www.blogger.com/profile/04647511597212113412noreply@blogger.com1tag:blogger.com,1999:blog-4065958629843931797.post-23415340911819137682010-02-10T20:13:00.000-05:002010-02-10T20:13:01.069-05:00New Clinical Research Project Now Enrolling PatientsThe UMBTC is beginning another clinical research study at MGH.<br />
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The study is entitled, "Is the presences of cytomegalovirus (CMV) in tumor tissue a prognostic factor for patients with newly diagnosed glioblastoma multiforme (GBM)?"<br />
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Background: CMV is a member of the herpesvirus family. Other members of this family include the viruses that cause chicken pox and mononucleosis. Between 50% and 80% of adults in the United States are infected with CMV by age 40. Most CMV infections are silent, causing no symptoms. CMV infection can be serious, especially when transmitted to an infant at birth or in a patient immunosuppressed because of medication (i.e. transplant patients) or HIV. Once CMV is in our body, it stays there, dormant, for life. Currently, there is no treatment for CMV.<br />
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Is there a link between CMV and GBM? In 2002, Charles Cobbs, a Neurosurgeon, first reported finding CMV DNA in GBM tumor samples. This result was confirmed by other investigators, including Duane Mitchell at Duke University.<br />
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</div><div class="MsoNormal">It is unlikely that CMV causes GBM. But because CMV related proteins have an effect on cell growth and survival, CMV may contribute to the aggressive behavior of GBM. For example, CMV might make tumor cells more resistant to chemotherapy and radiation therapy or it might help tumor cells evade the immune system.<o:p></o:p></div><div class="MsoNormal"><br />
</div><div class="MsoNormal">Study objectives: </div><div class="MsoNormal">1. Quantify the amount of CMV DNA that is present in tumor tissue. We plan to develop a test that will tell us how much, if any, CMV DNA is present in a specimen of tumor tissue. We will use a technique called real time polymerase chain reaction (PCR). For this test, DNA will be extracted from a small amount of tumor tissue removed at the time of surgery. </div><div class="MsoNormal">2. We will next determine if the presence of CMV DNA in GBM samples is an independent prognostic factor. That is, does a person whose tumor contains CMV DNA respond better or worse to treatment? We will also use statistical tests to determine if a particular level of CMV DNA can predict response to treatment.</div><div class="MsoNormal">3. If the results look promising, we hope to expand the study to include other brain tumor centers and pediatric patients.</div><div class="MsoNormal">4. If it turns out that CMV DNA has a negative impact on patients, new and specific treatments can be developed to target CMV.</div><div class="MsoNormal"><br />
</div><div class="MsoNormal">This study has been approved by the Institutional Review Board at MGH and the HIPAA compliance officer at MGH. That means that this study meets federal guidelines to protect a patient from harm and to protect confidential medical information.</div><div class="MsoNormal"><br />
</div><div class="MsoNormal">If you or your family have questions about this clinical research, please contact the UMBTC at 906-225-7739 or email us at info@hopestartshere.org.</div><div class="MsoNormal"><br />
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